Effect of Radiation on Fin Regeneration of the Fish, Oryzias latipes, with Special Reference to Dose-Rate
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概要
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Inhibitory effects of raddiation on the regeneration of fin of the fish, Oryzias latipes, irradiated before fin amputation was examined. Both whole body and local irradiation of the fin region alone suppressed the elongation of fin and prevent cell differentiation into fin rays dependent on the given dose. The earlier processes of the regeneration, wound healing andblastema formation, were relatively resistant to radiation. Reduction in the dose-rate resulted in a sparing effect on the radiation damage. In spite of the serious inhibition of the fin regeneration resulted from acute (250R/min) irradiation of 4kR, irradiation performed at exposure-rate reduced to 25 R/min or less did not prevent fin regeneration at least in the examination of the fin elongation. The fish fin is the system of non-proliferating or slowly dividing tissue, but has a capacity for rapid cell prolifaration in an emergency when partial amputation of the tissue is carried out. In the previous experiment, effect of radiation on the initiation of mitosis in the regenerating area of the caudal fin was examined in the fish irradiated before fin amputation. In the experiment special reference was taken to the dose-rate and temperature with the relations to the recovery of radiation damage. As the result, sparing effect of radiation resulted from the reduction of the dose-rate was observed and this effect was not found at low temperature. In the present experiment, in order ta know effects of radiation and effect of dose-rate on later processes of fin regeneration, the elongation of the regenerating area were compared under various conditions.
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