Effect of Head-Irradiation upon Epidermal Mitotic Activity during Wound Healing in the Adrenalectomized Mice
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Epidermal mitotic activity during wound healing was estimated both in the adrenalectomized, head-irradiated mice and in the adrenalectomized, non-irradiated mice, and was compared with those obtained previously from the unoperated, head-irradiated mice. It was found that head-irradiation caused a mitotic depression to a much smaller extent in the adrenalectomized mice than it did in the unoperated mice, though adrenalectomy itself had exerted a great inhibitory effect upon the mitosis induced by an injury. Whether this abscopal effect of head-irradiation upon the mitotic activity was mediated via the adrenals, and whether in the adrenalectomized mice the head-irradiation acted to increase epidermal response to injury, making the mitotic pattern of adrenalectomized mice to come near that of control mice were discussed. Abscopal effects of irradiation were recognized early in the history of radiation biology. Several different mechanisms of action may be responsible for abscopal effect. It is known that mitotic activity during regeneration of kidney was affected considerably by abscopal means of irradiation. In a previous paper it was shown that injury-induced epidermal mitosis was markedly inhibited by local effect of irradiation and mitosis also could be inhibited diversely by abscopal means. From the comparison of the mitotic pattern between differently irradiated groups it was suggested that pituitary-adrenal axis might have a role in the occurrence of abscopal effects of head-irradiation.
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