The Role of Spermatogonia in the Recovery Process from Temporary Sterility Induced by Gamma-Ray lrradiation in the Telecst Oryzias latipes

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Adult males of the fish Oryzias latipes were irradiated with 0.5 or 1 kR of ^<137>Cs-gamma-rays (100R/min). From the viewpoint of the cell-population shift and cell differentiation, the radiation effects on the spermatogenesis in the testis were analyzed. Among the three types of spermatogonia, the first type, the spermatogonia As, were very resistant to radiation, judging from the survival of the cells, but the other types, the spermatogonia Ad and the spermatogonia B, were sensitive to radiation. The spermatogonia As began to proliferate after the degeneration and disappearance of the spermatogonia Ad following the irradiation. During the proliferation phase of the cells, some of the spermatogonia As were morphologically transformed into the spermatogonia Ad, which contributed to the repopulation of the spermatogenetic cells in the testis following the cell loss induced by radiation damage. It has been demonstrated by several workers that, in fishes as in mammals, some spermatogonia and spermatocytes are particularly sensitive to ionizing radiation. In fish given 0.5-2kR of X-rays, spermatogenesis was temporarily inhibited and recovered from the radiation damage, showing a number of spermatocytes and spermatids newly formed from the spermatogonia which had been dormant at the time of the irradiation. However, the nature of the dormant spermatogonia has not been investigated.
日本放射線影響学会の論文