Restoration of Radiation Injury by Intraperitoneal Injection of Ginseng Extract in Mice

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A single intraperitoneal injection of partially purified ginseng extract after X-irradiation of 650-675 R significantly increased the 30-day survival ratio in mice. Death of mice occurring 10 to 20 days after whole-body exposure to ionizing radiation is primarily produced by the damages of blood-forming tissues, and is called bone marrow death. Recently, stimulating action of ginseng (roots of Panax ginseng C. A. Meyer) on rat bone marrow and other tissues have been investigated. Oral administration of a ginseng extract resulted in an increase of the number of mitotic cells both in myeloid and erythroid cells. Intraperitoneal injection of the extract also increased the rate of syntheses of serum albumin and gamma-globulin as well as DNA, RNA, protein and lipid syntheses in bone-marrow cells. Several saponins such as ginsenoside-Rb2, Rc, and Rg1 are though to be the active comonents of the ginseng extract. Here we studied the restorative effect of the ginseng extract in mice given an acute dose of X-irradiation, expecting that it might protect the irradiated mice from death by increasing mitosis of the surviving bone-marrow cells.
日本放射線影響学会の論文