Mechanisms of the Synergistic Interaction between Hyperthermia and Radiation in Cultured Mammalian Cells

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概要

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• Hyperthermia and radiation interact synergistically in cultured mammalian cells. Data pertaining to the subject are reviewed and mechanisms to explain the phenomena are proposed. One may involve changes in chromosomal structure at high temperatures. These changes make the chromosome less amenable for repair of radiation damage. A second mechanism consists of endonucleolytic degradation of DNA in hyperthermic cells after radiation. This may be ascribed to imbalance between degradation and resynthesis processes operating during repair of DNA damage. Modification of the response of mammalian cells to ionizing radiation is important for theoretical as well as practical reasons. It sheds light on the mechanisms by which radiation kills cells. Practically, improvement in radiation therapy of cancer becomes possible. This is why extensive work has been done concerning the radiobiology of cultured mammalian cells and factors affecting their radiosensitivity (see Elkind and Whitmore, for review).

• 日本放射線影響学会の論文

著者

• Ben-hur E.

  Atomic Energy Commission Nuclear Research Centre-negev

関連論文

• Mechanisms of the Synergistic Interaction between Hyperthermia and Radiation in Cultured Mammalian Cells

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