Effect of X-irradiation on the Permeability of L-Alpha Hydroxy Acid Oxidase From Mouse Liver Peroxisomes
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概要
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Mice were exposed to 800 R whole body X-irradiation at a rate of 15 R per minute. Following exposure there was an increase in the permeability of L-alpha hydroxy acid oxidase from mouse liver peroxisomes, and an increased sensitivity of the peroxisomes to low concentrations of Triton X-100. These results indicate that latency characteristics of peroxisomes from irradiated animals are altered compared to the latency characteristics of peroxisomes from control animals. Peroxisomes (microbodies), the cytoplasmic organelles originally first described in kidney and then in liver, have recently been recognized as ubiquitous structures in animal and plant cells. These particles, Iimited by a single membrane, contain catalase and several oxidative enzymes. It appears that catalase is the only constant component of peroxisomes derived from different sources, whereas the hydrogen peroxide-generating oxidative enzymes differ in number and specificity.
- 日本放射線影響学会の論文
- 1974-12-00
著者
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Brown P.c.
Department Ot Biotogy San Diego State University San Diego: (present Address) University Of Tennessee Oak Ridge Graduate School Of Biomedical Sciences Biology Division Oak Ridge National Laboratory
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KLElNBERGS-KRISANS S.
Department ot Biotogy San Diego State University San Diego