Retention of Cadmium in Mice Studied by Whole Body Autoradiography

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The time-course of cadmium distribution in mice was investigated for up to 180 days after administration of ^<109>Cd by whole body autoradiography and by radioactivity counting. Accumulated ^<109>Cd was excreted hardly from the body and remained mainly in liver, kidneys and pancreas for a long time. The pattern of retention of ^<109>Cd was varied with organs : in liver, gastrointestinal wall and salivary glands, the concentration of ^<109>Cd was decreased with time ; in pancreas, spleen and lungs, it was hardly decreased ; in kidneys, it was increased. Liver retained larger amount of ^<109>Cd than any other organ even after long period. In kidneys, most of ^<109>Cd was retained in their cortex. Since some of heavy metals are known to be environmental pollutants, numerous investigation has been carried out to study nature of their toxic effects and their metabolisrn in bodies. In order to deepen the understanding of cadmium metabolism, the studies on the transport, distribution, retention and excretion of cadmium has been performed.
日本放射線影響学会の論文