Effects of DTPA on the Excretion and Tissue Distribution of ^<144>Ce Administered Subcutaneously, Intramuscularly and Intravenously in Rats

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A chelating agent, trisodium calcium salt of diethylenetriaminepentaacetic acid (DTPA), was administered intraperitoneally with a single dose of 1.5 mM (750 mg)/kg body weight to rats 1 hr after subcutaneous, intramuscular or intravenous injection of ^<144>CeCl_3. Daily urinary and fecal excretion of ^<144>Ce was determined for 15 days postinjection. Tissue distribution of ^<144>Ce 15 days postinjection was also determined. The DTPA markedly increased the urinary excretion of subcutaneously and intramuscularly injected ^<144>Ce as well as of intravenously injected one, and decreased the contents of ^<144>Ce in all the tissues observed. It was suggested that a prompt DTPA treatment followed by intermittent therapy might be effective for the removal of ^<144>Ce transferred from the contaminated wounds and that in the wounds.
日本放射線影響学会の論文