Radiation-induced Chromosomal Aberration in Relation to DNA Synthesis

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概要

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• Using autoradiographic technique with ^3H-TdR as a marker for DNA synthesis, the average duration of the each phase of mitotic cycle in barley roots was estimated and was found to be as follows: G_1 (pre-DNA synthesis stage) 4.5 hrs. , S (DNA synthesis stage) 4.5 hrs. , G_2 (post-DNA synthesis stage) 4 hrs. , and M (mitosis) 2 hrs. Autoradiographic studies also showed that an asynchronous replication of DNA was occurring in a barley chromosome, terminal portions of the chromosome arms being first replicated. The examination of radiation-induced terminal deletions in anaphase cells revealed that chromosome sensitivity changed according to the stage of the cell cycle at which the cells were irradiated. The chromosome was more sensitive in late S and G_2 than in G_1, and the most sensitive in early S and/or late G_1. It was discussed that DNA is a primary target for cell killing caused by irradiation.

• 日本放射線影響学会の論文

著者

• 山元 皓二

  Laboratory of Plant Breeding, Faculty of Agriculture, University of Tokyo

• 山口 彦之

  Laboratory Of Radiation Genetics Faculty Of Agriculture University Of Tokyo

• 山元 皓二

  Laboratory Of Radiation Genetics Faculty Of Agriculture University Of Tokyo

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