Protection Mechanisms of Non-malignant and Malignant Cells against Ionizing Radiation I. The Cytological Effects of 2-mercaptoethylamine on the Rat and Mouse Ascites Tumors

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概要

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• The present study deals with cytological effects of 2-mercaptoethylamine on the Yoshida-sarcoma, the MTK-sarcoma III and Ehrlich ascites tumor concentrating a special attention on cell growth of tumor. 2-Mercaptoethylamine exerts influence upon tumor cells in process of mitosis, especially on an increase of mitotic cells, leading to increase of prophasic cells at first and metaphasic cells secondarily. The protection mechanism against radiation exerted by 2-mercaptoethylamine indicated that this drug induced an increase of mitotic activity. This increase of mitotic activity might be interpreted as a protecting effect against radiation injury.

• 日本放射線影響学会の論文

著者

• 河村 文夫

  徳島大学医学部

• 河村 文夫

  Department of Medical Radiology, School of Medicine, Tokushima University

• 小林 仁道

  Department of Medical Radiology, School of Medicine, Tokushima University

• 小林 仁道

  徳島大学医学部放射線医学教室

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