Carcinostatic Effect of Extracts from Human Gastric Cancer

概要

論文の詳細を見る
Saline extracts from human gastric cancer divided into two parts, one of which was irradiated by X-ray of 2000 r, before homogenization, were fractionated with EtOH, in which S_1 was 30% vol. ppt. , S_2 was 30-70% vol. ppt. , and S_3 was supernatant. Further, S_1 and S_2 were fractionated with (NH_4)_2SO_4 into P_1 (30% sat. ppt.), P_2 (30-50% sat. ppt.), P_3 (50-7O% sat. ppt.), and P_4 (supernatant). The S_2P_1 and S_2P_2 fractions non-irradiated inhibited the growth of subcutaneous solid Ehrlich ascites tumor in mice, which were respectively significant at the level of 10% and 5%, but the same fractions irradiated lost the growth inhibitory activity. The S_2P_3 fraction irradiated inhibited the growth of solid tumor at the level of 20%, and was different from the equivalent non-irradiated fraction having mitosis promoting activity at the significance of 0.5% level. These data may show that malignant tumor contains the growth inhibiting substance which is not species specific, and the carcinostatic effect of X-ray irradiation is due to the destruction of balance between growth promoting and inhibiting substances inside of the tumor tissue.
日本放射線影響学会の論文