Effects of γ-Irradiation on Glycolytic Control Mechanisms in Ehrlich Ascites Tumor Cells

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概要

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• Intracellular concentrations of intermediates and cofactors of glycolysis were measured in γ-irradiated Ehrlich ascites tumor cells. Changes in the levels of intermediates and comparison of mass-action ratios with the equilibrium constants for the reactions of glycolysis revealed a remarkable enhancement of phosphofructokinase activity and inhibitions at the triosephosphate dehydrogenase and pyruvate kinase steps. The possible mechanisms involved in the alteration of these regulatory enzymes in glycolysis were discussed.

• 日本放射線影響学会の論文

著者

• 山田 武

  Division of Biology, National Institute of Radiological Sciences

• 山田 武

  Division Of Biology National Institute Of Radiological Sciences

関連論文

• Abolition of the Crabtree Effect in Ehrlich Ascites Tumor Cells by γ-lrradiation
• X-ray Effects on the Glycolytic Regulatory Enzymes in Rat Thymocytes and their Modification by Cysteamine
• Effects of γ-Irradiation on Glycolytic Control Mechanisms in Ehrlich Ascites Tumor Cells
• The Mortality and Body Weight Response of Male Wistar Rats in the Lethal X-ray Dose Range
• Effect of Protein Synthesis Inhibitor on Accumulation of Fructose-1, 6-diphosphate in Irradiated Rat Thymocytes

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