Studies on Radiolysis of Amino Acids and Proteins : I. On Radiolytic Oxidation of Sulfhydryl Groups

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概要

• 論文の詳細を見る

• By relatively small doses of γ-irradiation, inactivation of sulfhydryl enzymes such as alcohol dehydrogenase and urease, were proved to be induced. This inactivation was recovered reversibly by the addition of thiol compounds such as cysteine and glutathione. In the course of radiolysis of cysteine, measurable decrease in the amount of sulfhydryl group was found to occur by the small doses of the irradiation and, of course, by large irradiation doses. Such decrease in the amounts of sulfydryl group was found to occur also on the sulfhydryl enzyme proteins. Moreover, the lost activities in the inactivation of the enzymes was proved to be corresponding to the decrease of the sulfhydryl groups. A valid evidence, thus, was added to the mechanism of inactivation of sulfhydryl enzymes by ionizing radiation.

• 日本放射線影響学会の論文

著者

• 波多野 博行

  Department of Chemistry, Faculty of Science, Kyoto University

• 波多野 博行

  Department Of Chemistry Faculty Of Science Kyoto University

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• Chemical and Enzymatic Properties of ^Co γ-Ray Irradiated Subtilisin BPN'
• Radiolysis of Cystine in Aqueous Solution by Gamma Irradiation
• Studies on Radiolysis of Amino Acids and Proteins : III. On Radiolysis of Peptides and Proteins in Aqueous Solutions by Gamma Irradiation
• Studies on Radiolysis of Amino Acids and Proteins : II. On Radiolytic Deamination of Amino Acids in Aqueous Solutions by Gamma Irradiation
• Studies on Radiolysis of Amino Acids and Proteins : I. On Radiolytic Oxidation of Sulfhydryl Groups

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