脳腫瘍に対するインターフェロン治療(第2報) : DNA定量と平均生存期間
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概要
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The effect of interferon (human interferon-α; IFN) on the primary brain tumors has been reported. A decrease in the tumor volume of less than 50% of the initial volume was observed in two out of seven cases of systemic administration of IFN, and in two out of eight cases of daily local ad-ministration. Changes of the DNA pattern in the tumor tissue, of performance status of the pa-tients, and of the mean survival time after IFN therapy were investigated. DNA histograms were obtained by cytofluorometry on 6 glioblastomas and 2 medulloblastomas before and after IFN therapy. In the two clinically effective cases, a decrement of the S phase and an increment of the G_0, G_1 phases were observed after IFN therapy. These findings might reflect in-hibition of cell transition from G_0, G_1 phases into the S phase by IFN. Performance status and mean survival time of the IFN treated group (12 cases of glioblastoma) were compared with 53 previous cases of malignant astrocytoma and glioblastoma, treated by surgery and irradiation. The Karnofsky performance status for pre- and post-IFN therapy was 5O.8% and 27.5%, respectively. These statuses were similar to those for the pre- and post-third operation (48.3%, 23.3%) for the recurrent malignant gliomas. Furthermore, the mean survival times after second operation were 10.9 months through IFN therapy, and 9.7 months through third operation, respectively. Therefore, it was concluded that IFN therapy might be as effective as the third operation for recurrent malignant gliomas.
- 日本脳神経外科学会の論文
- 1984-02-15
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- 脳腫瘍に対するインターフェロン治療(第2報) : DNA定量と平均生存期間