サルの実験的脳浮腫における局所の脳血流量

概要

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Four to 5 months after exposure of the right occipital lobe of the monkey to 3500 rads of X-irradiation there is a proliferative and degenerative lesion accompanied by a massive break in the blood brain barrier. The resulting vasogenic edema caudes gross swelling in the ipsilateral hemisphere, compression of the contralateral hemisphere with ventricular dilatation, and distortion of midline structures, which may result in herniation through the incisura and the foramen magnum. The regional cerebral blood flow, determined by ^<14>[C] antipyrine method, at successive stages in the development and resolution of the delayed brain swelling shows a reduction of blood flow in the white and gray matter, first regionally, then throughout the ipsilateral hemisphere and finally throughout the whole brain. This fact may be explained by an increase of the local tissue pressure in the early stage, and an increased general pressure that is a decease of the cerebral perfusion pressure in the late stage. In the stage of resolution of CSF pressure the cerebral blood flow shows moderate recovery in the whole brain, but there remains a diffuse depression suggesting a long term impairment in cellular metabolism and/or blood flow mechanism.
日本脳神経外科学会の論文