Blood Levels of Polyamines in Patients with Brain Tumor: Special Reference to Relationship between Blood Levels of Polyamines and Histological Finding, Extension as well as Treatment of Tumor
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In 38 patients with brain tumor and 17 controls, the blood levels of polyamines were measured, and studies were made on the relationship between these levels and varieties of tumors. In the group of 21 patients with glioma, these levels were significantly higher than those in the control (p<0.01), and in 14 out of 21 patients (67%) the levels exceeded the upper limit of normal range. In one patient with reticulum cell sarcoma, these levels were remarkably high. In the group of 4 patients with metastatic brain tumor, these levels were significantly higher than those in the control (p<0.05), and in 2 of 4 patients the levels exceeded the upper limit of normal range. The levels were all within normal range in 4 patients with neurinoma, 3 patients with meningioma, 2 patients with pituitary adenoma, 1 patient with pinealoma, and 1 patient with cerebellar hemangioblastoma. In 18 patients with glioma, studies were also made on the relationship between the blood levels of polyamines and the degree of histological malignancy and of extension of tumor. There was no significant difference in these levels between the control and the group of astrocytoma localized within a lobe, but the levels were significantly higher in the group of astrocytoma extending more widely and in the groups of anaplastic glioma or glioblastoma multiforme regardless of their size. In patients with glioma, the blood levels of polyamines before and after treatment were compared. In 3 patients subjected to surgical excision, irradiation and chemotherapy these levels were all within normal range after treatment, but in a case treated by irradiation and chemotherapy the values increased immediately after treatment.polyamine, spermidine, spermine, cell proliferation, brain tumor, diagnosis
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