Chromosome Analysis of Experimental Rat Glial Tumor(1)-Correlation of chromosome changes between glial tumors and fetal brain tissue of rats after a transplacental exposure to ethylnitrosourea

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Chromosomal constitution of 7 rat glial tumors induced by methylnitrosourea (MNU) and ethylnitrosourea (ENU) was investigated. Cells from rat glial tumors showed preferentially complete monosomy for #3 chromosomes and partial monosomv for #2 chromosomes. Numerical and morphological changes in #11 and #12 chromosomes were also observed. These chromosome aberrations have no relation with histological classification of experimental rat gial tumors. One #3 chromosome missing in neolplastic glial tumors was constantly observed through a long term culture and had no relation with the appearance of marker chromosome. These chromosome changes were compared with the preferential involvement of #1 and 2 chromosomes in fetal brain cells of rats shortly after a transplacental administration of ENU.
社団法人日本脳神経外科学会の論文