The Effect of Osmotic Pressure on the Production of Cerebrospinal Fluid

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The effect of the osmotic gradient between plasma and CSF on the talc of CSF formation was studied in rabbits using the ventriculo-cisternal perfusion technique. The rate of formation of CSF in the control animals with isosmolar perfusion was found to be 10.9±0.5 μl/min. In order to raise the plasma osmolality, 20% mannitol was intravenously administered as a bolus after a steady-state condition of perfusion was attained. Rapid readjustment of plasma osmolality was observed after the mannitol injection, though the osmotic gradient was reversed for CSF formation throughout the 3-hour period of perfusion. In spite of such an adverse osmotic gradient, the rate of the bulk formation of CSF was still maintained by more than 50% of the control value. Hypertonic perfusion was performed by adding NaCl or monosaccharides into the perfusion fluid. A remarkable increase in the rate of formation of CSF was observed in the NaCl perfusion, after a steady state was achieved in the perfusion system, while in the monosaccharide perfusion, the increase in the rate of formation of CSF was not only less marked but also of shorter duration, despite the increased osmolality of the perfusate. In face of the experimentally imposed osmotic gradient between both sides of the choroidal epithelium, the osmotic flow of water across the ependyma may take part in the mechanism of CSF production. However, when such an osmotic gradient is produced by nonelectrolytes, homeostatic regulation of CSF formation may take place. In such a mechanism, Na^+ ion is likely to play a role as a regulatory factor.
社団法人日本脳神経外科学会の論文

The Effect of Osmotic Pressure on the Production of Cerebrospinal Fluid

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