Effects of Hypercapnia and Papaverine on Cerebrospinal Fluid Formation and Choroid Plexus Blood Flow

スポンサーリンク

概要

• 論文の詳細を見る

• Changes in the cerebrospinal fluid (CSF) formation rate (Vf) with hypercapnia and papaverine infusion were measured by the ventriculocisternal perfusion technique in anesthetized dogs. In addition, local blood flow in the choroid plexus and cerebral cortex was measured by the hydrogen clearance method. When PaCO<SUB>2</SUB> increased with 10% CO<SUB>2</SUB> inhalation, Vf increased transiently and gradually decreased to the control level within an hour. This transient increase in Vf is considered to be due to mobilizing unequilibrated pools of CSF, caused by sudden changes of the craniospinal blood volume. Excluding such an apparent increase caused by an artifact, neither hypercapnia nor papaverine affected Vf.<BR> Local blood flow of the choroid plexus of 12 normal dogs was 72.8±13.1 ml100 gmin in average which was higher than that of the cerebral cortex; 57.8±12.4 ml 100 gmin. Although cortical blood flow increased to 225% of the control under hypercapnia with 10% CO2 inhalation, the choroid plexus blood flow did not increase significantly. Papaverine infusion also raised the cortical blood flow up to 143% of the control, while the choroid plexus blood flow did not increase significantly. From the above results, the choroid plexus, a major source of CSF, is demonstrated to be less reactive to vasodilatation induced by either hypercapnia or a vasoactive agent. This phenomenon favorably explanes, at least partially, the unchanged Vf under the effect of hypercapnia or papaverine.

• 日本脳神経外科学会の論文
• 1985-01-15

著者

• Higashi Kenichiro

  Neurosurgical Service Massachusetts General Hospital And Harvard Medical School:second Surgical Depa

• KATAYAMA Sanao

  Department of Neurosurgery,Kokura Memorial Hospital

• Katayama Sanao

  Department Of Neurosurgery Kokura Memorial Hospital

• HIGASHI Kenichiro

  Neurosurgical Research Institute,Kitakyushu Central Hospital

関連論文

• Effects of Hypercapnia and Papaverine on Cerebrospinal Fluid Formation and Choroid Plexus Blood Flow
• 65 65. Studies on the Newly Formed Choroid Plexus Fluid : Relation of K Concentration in Choroid Plexus Fluid to K Concentration in Plasma; and Effects of pCO_2, Acetazoleamide and Ouabain on Volume and Composition of Choroid Plexus Fluid

スポンサーリンク