Comparative Study of Chemotherapy and/or Immunotherapy of Established Experimental Brain Tumors
スポンサーリンク
概要
- 論文の詳細を見る
Intracerebral injection of 5 × 10^5 nitrosourea-induced glioma cells (T_9 tissue culture line) consistently produced brain tumors in syngenic Cesarean Derived Fisher rats. The tumors were 1 mm in diameter within 7 days and caused death within 23 days (mean results). The effects of therapy with ACNU and/or Corynebacterium parvum (C. parvum) were evaluated. C. parvum alone was apparently in-effective. ACNU (10 mg/kg body weight) given on days 7 and 14 prolonged the mean survival time to 33.4 days. Combined treatment with ACNU and intradermal immunization with T_9 cells and C. parvum on days 7 and 14, or on days 0 and 7, prolonged the mean survival time to 35.3 and 39.6 days, respectively. Eleven rats that survived following this treatment showed specific immunity against T_9 cells, as demonstrated by subsequent challenge with T_9 cells. The Winn's test procedure showed that spleen lymphocytes from immune rats were effective against T_9 cells. The results suggest that immunochemotherapy may be an effective treatment for rats with established brain tumors.
- 日本脳神経外科学会の論文
- 1985-07-15
著者
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Kida Yoshihisa
Department Of Neurosurgery Kamo Hospital:(present Address)department Of Neurosurgery School Of Medic
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Cravioto Humberto
Department Of Pathology New York University Medical Center
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Kida Yoshihisa
Department Of Neurosurgery Gamma Knife Center Komaki City Hospital
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