Immunohistochemical Demonstration of S-100 Protein in Meningioma

概要

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A total of 50 meningiomas was immunohistochemically examined for the presence of S-100 protein, an extremely acidic protein unique to the nervous system, by the peroxidase-antiperoxidase technique. Nineteen out of 50 meningiomas revealed unequivocally positive immunoperoxidase staining for S-100 protein. The distribution pattern of S-100 protein positive cells in these 19 meningiomas could be classified into three different types: diffuse (5/19), sparse (7/19) and clumpy (7/19) distribution of the positive cells throughout the sections. At present it is generally believed that S-100 protein is observed solely in the cells of either neuro-ectodermal or mesenchymal origin; therefore, the present immunohistochemical results strongly suggest that meningioma may consist of a variety of tumors with different histogenesis in terms of S-100 protein.
日本脳神経外科学会の論文
1984-07-15