無脾臓無胸腺および無胸腺ヌードマウスのヒト神経膠腫の移植 : 神経特異蛋白産生長期継代腫瘍の確立

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Attempts were made to transplant five human brain tumors consisting of one meddulloblastoma, one anaplastic astrocytoma, one glioblastoma and two pituitary adcnomas into hereditary asplenic-athymic (Iasal) mice. One tumor line designated as KNS-GL-2 was established from the anaplastic astrocytoma. The tumor transplanted serially through two to four generations in lasat mice showed tumor growth in athymic nude mice as well and could be serially passaged. As the serial passage advanced, both the rate of tumor takes and the growth rate increased, and the tumor became more infiltrating. Tumors developed in mice showed good compatiblity with the original tumor in histological and ultrastruetural characteristics in early passages of one to three generations, and immunoperoxidase positive tumor cells were iderntifiecl in GFAP and S-100 protein preparations. Tumor cells with small, dark cytoplasm appeared in the third generation and they became predominant thereafter. Only the large and clear cells showed positive reactions in both GFAP and S-100 protein preparations. Dedifferentiation or malignant transformation by serial passage was suggested.
日本脳神経外科学会の論文
1980-12-15

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