Human Monoclonal Antibody-Drug Conjugates in the Experimental Treatment of Malignant Gliomas : Studies In Vitro and In Vivo
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概要
- 論文の詳細を見る
The chemotherapeutic agents doxorubicin (DXR) and 4'-epi-doxorubicin were separately conjugated to the human monoclonal antibody CLNIgG, which binds strongly to human malignant glioma cells. The antibody-drug conjugates were more potent than the free drugs in killing human glioma cells in vitro and in vivo (subcutaneous glioma model). A biodistribution study using [14-^<14>C] DXR-CLNIgG conjugate indicated that immunoconjugates delivered at least five times more DXR to glioma tissues than free DXR alone in nude mice without increasing the concentration in other tissues. In a nude rat intracerebral glioma model, intracarotid hyperosmolar perfusion to achieve blood-brain barrier (BBB) opening caused a 640% increase in the DXR-CLNIgG concentration in intracerebral tumor tissue. Human monoclonal antibody-drug conjugates in combination with BBB opening is a potential new approach to the treatment of malignant gliomas.
- 日本脳神経外科学会の論文
- 1994-05-15
著者
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Takahashi Hiroshi
Department Of Cardiology Nihon University Surugadai Hospital
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Nakazawa Shozo
Department Of Neurosurgery Niigata University
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Nakazawa Shozo
Department Of Neurosurgery Nipon Medical School
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ZHU Jianhong
Department of Neurosurgery, Nipon Medical School
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Zhu Jianhong
Department Of Neurosurgery Nipon Medical School
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Takahashi Hiroshi
Department Of Applied Aquabiology National Fisheries University
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Takahashi Hiroshi
Department Of Neurosurgery Nipon Medical School
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