Enhanced Secretion of Endothelin by Endothelial Cells in Response to Hemoglobin
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概要
- 論文の詳細を見る
Confluent cultures of bovine aortic endothelium in serum-free medium were exposed to increasing concentrations (10^<-6>-10^<-4> M) of freshly prepared erythrocyte lysates (primarily hemoglobin). Hemoglobin increased endothelin-1 secretion into the medium in a dose-dependent manner after 24 hours. The enhanced secretion of endothelin-1 in response to hemoglobin was sustained for 72 hours, suggesting active production and secretion of endothelin-1 rather than release from intracellular pools. Secreted endothelin-1 in the medium was characterized by high-performance liquid chromatography coupled with radioimmunoassay. Endothelin-1, a potent and long-lasting vasoconstrictor, may be one of the causative factors of cerebral vasospasm after subarachnoid hemorrhage. Oxyhemoglobin, derived from periarterial clot, may play an important role in the secretion of endothelin-1 in cerebral vasospasm.
- 1993-11-15
著者
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Fuwa Isao
Department Of Neurosurgery University Of Washington:m.d. Division Of Neurosurgery Minamata General M
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Mayberg Marc
Department Of Neurosurgery University Of Washington
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Mayberg Marc
Department Of Neurological Surgery University Of Washington
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Harada Tsutomu
Department Of Neurosurgery University Of Washington
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GADJUSEK Corinne
Department of Neurosurgery, University of Washington
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LUO Zhengyu
Department of Neurosurgery, University of Washington
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Luo Zhengyu
Department Of Neurosurgery University Of Washington
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Gadjusek Corinne
Department Of Neurosurgery University Of Washington
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