Characterization of Immobilized Anti-CD3 Antibody-activated T Lymphocytes for Use in Adoptive Immunotherapy of Patients with Brain Tumors

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概要

• 論文の詳細を見る

• Large numbers of T lymphocytes were successfully cultured for use in adoptive immunotherapy using immobilized anti-CD3 antibody. This method allows more than 1.5×10^<10> T lymphocytes to be cultured within 2 weeks from only 20ml of blood. Proliferated T lymphocytes were less cytotoxic than lymphokine-activated killer cells induced with a high dose of interleukin-2, but were more specific for autologous tumor cells as determined by cold target competition. Signal transduction of anti-CD3 antibody induced a population of CD8 positive cells, i.e. cytotoxic T lymphocytes. Adoptive immunotherapy using autologous lymphocytes requires a sufficient number of lymphocytes and high induced cytotoxic activity. This method is promising for clinical adoptive immunotherapy of patients with brain tumors.

• 日本脳神経外科学会の論文
• 1992-05-15

著者

• Sekine Teruaki

  Research Institute National Cancer Center

• Yamazaki Takamasa

  Department Of Neurosurgery School Of Medicine Toho University

• Yamazaki Takamasa

  Department Of Neurosurgery Sakura Hospital Toho University School Of Medicine

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• Characterization of Immobilized Anti-CD3 Antibody-activated T Lymphocytes for Use in Adoptive Immunotherapy of Patients with Brain Tumors

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