定常空気呼吸時の血漿内pHの分析

概要

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pH in blood plasma depends not only on Pco_2, but also on the bicarbonate concentration ([HCO_3^-]). [HCO_3^-] has a Pco_2-dependent respiratory component([HCO_3^-]^*), and a Pco_2-independent metabolic component ([HCO_3^-]^o). [HCO_3^-]^* can be approximated by a defined exponential function of Pco_2. When [HCO_3^-]^o = 0, let [H^+] and pH be designated by [H^+]^* and pH^*, respectively. At any value of Pco_2, the deviation of pH^* from 7.4 (pH^*-7.4) is given by the Henderson equation as a linear function of log Pco_2. At a given Pco_2, the difference between pH and pH^* (pH-pH^*) at any [HCO_3^-]^o is given by the common logarithm of the ratio ([HCO_3^-]/[HCO_3^-]^*). The effects of Pco_2 and [HCO_3^-]^o on acid-base balance can be accurately analysed by using the equatons for pH^*-7.4 and pH-pH^*, derived from the Henderson equation, together with the exponential function of Pco_2 for [HCO_3^-]^*. The use of the equation in defining acid-base status is illustrated here by application to results from elderly patients and healthy volunteers.
山形大学の論文
2005-02-16