[ORIGICAL ARTICLE]Adrenocortical Response to Tail-Suspension in Young and Old Rats

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概要

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• We recently showed that increased glucocorticoid secretion aggravates disuse atrophy when induced by skeletal unloading. Disuse atrophy in the elderly is becoming a serious problem in many developed countries. In this study we attempted to examine how aging affects the glucocorticoid response to skeletal unloading. Three groups of rats(aged 5 weeks, 12 months and 18 months) were subjected to 7 days of hind limb unloading by tail-suspension. Urinary excretion of corticosterone over a 24-hr period were monitored every other day. Corticosterone excretion in the control group of 5-week-old rats was initially 87.4±12.8 ng/day and did not change throughout the experiment. Tail-suspension experiments yielded a signifficant increase (more than 3 fold) in excretion on days 1 and 3 of the suspension before returning to control levels. In the 12-month-old rats, a marked increase in the basal corticosterone level was observed in the control rats throughout the experiment, while the increase by tail-suspension was attenuated with a transient, signifficant increase on day 5. In 18-month-old rats, a further increase in the basal level was observed in the control group, although excretions tended to increase steadily from day 1 to day 3 and remained hight until day 7. Urinary excretion of cortiosterone among the 18-mounth-old suspension group was smimilar those observed in the control group.These results indicate that the younger (5-week-old) rats adaped the stress load caused either by tail-suspension or manipulation alone faster than the older rats did (12 or 18 months old). The observation that basal corticosterone excretion increases with age suggests, alterations in the hypothalamic-pituitary-adrenal axis among the aged rats which might aggravates disuse atrophy induced by skeletal unloading.

• 名古屋大学の論文

著者

• KANDA Kazumi

  Department of Endocrinology and Metabolism Division of Molecular Adaptation Research Institute of En

• Ohmori Sachiko

  名古屋大学環境医学研究所

• Ohmori S

  Department Of Endocrinology And Metabolism Division Of Molecular Adaptation Research Institute Of En

• Ohmori S

  Nagoya Univ. Nagoya Jpn

• Kawano Setsuko

  名古屋女子大学

• Kawano S

  Nagoya Women's University

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