LEVELS OF PROSTAGLANDlN F_<2α>, E_2, IN THE HUMAN UTERlNE TISSUES AND IN HUMAN FALLOPIAN TUBES FROM NONPREGNANT WOMEN

概要

論文の詳細を見る
Tissue samples were obtained from 3O women between the ages 16 and 44 with normal regular menstrual cycles, from 30 women between the ages 31 and 52 with uterine myoma, and from 4 women between the ages S7 and 58 with uterine cervical carcinoma in situ (Abb. CIS). The levels of prostaglandins (Abb. PGs) were determined by radioimmunoassay (Abb. RIA), and PGES were identified and assayed by gas chromatography mass spectrometry (Abb . gas-mass). Levels of PGF_<2α> and E_2 in normal menstrual cycles changed periodically as previously reported. The levels of PGF_2 and E_2 in the uterine tissues from the women with uterine myoma were significantly highest in the endometrium, and were higher in the uterine cervix than in the uterine corpus. Those in the Fallopian tubes were higher at the ampullar region than at the isthmic one. The levels of PGS by the method of gas-mass in the uterine tissues and in the Fallopian tubes were almost the same as those determined by RIA. Though PGE_1 and PGE_2 existed, PGE_3 could not be detected. PGS play important roles in reproduction.
社団法人日本産科婦人科学会の論文
1981-01-01