OSCILLATION OF MEMBRANE POTENTIAL SYNCYTIOTROPHOBLAST OF HUMAN TERM PLACENTA IN CULTURE

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The membrane potentials and resistances of the cultured syncytiotrophoblast of human chorionic villi obtained from normal term placentas were measured using a standard electrophysiological technique. The mean value of membrane potentials and resistances for 156 cells in the control tris-buffered saline at 370C were -40.^}1.2mV and 8.6±O.7MΩ (mean ± S.E.), respectively. The membrane potential was markedly affected by the change of external, concentration of Ca or K+. In 32 cells among 156 cells examined, spontaneous oscillations of membrane potentials were observed. They oscillated between around -38mV and -57 mV with the average frequency of 2.4±O.2 times per minute, accompanied by decrease in membrane resistance on each hyperpolarization . Although oscillations of membrane potentials have been observed in other cultured cells, this is the first report on the oscillation of membrane potential in the human trophoblast.
社団法人日本産科婦人科学会の論文
1981-01-01