EFFECT OF 17-HYDROXYPROGESTERONE UPON HUMAN OVARIAN FUNCTION AND ITS APPLICATION ON THE TREATMENT OF THE SHORT LUTEAL PHASE

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In order to clarify pharmacological effect of 17-hydroxyprogesterone upon ovarian function in the women, 17-hydroxyprogesterone was administrated intramuscularly to ovulatory and castrated women, and plasma levels of FSH, LH, estradiol and progesterone were assayed. Intramuscular administration of 10 mg of 17-hydroxyprogesterone to 6 normal or sterile women in the follicular phase neither changed significantly plasma levels of FSH, LH, estradiol and progesterone, nor influenced the time of ovulation, nor suppressed ovulation. Intramuscular administration of 10 mg of 17-hydroxyprogesterone to 2 women in the ovulatory and the luteal phase changed neither significantly the duration of luteal phase, nor plasma levels of FSH, LH, estradiol and progesterone in the luteal phase. Intramuscular administration of 10 mg or 20 mg of 17-hydroxyprogesterone to 2 castrated women did not change plasma levels of FSH and LH. On the other hand, daily or every other day's administration of 4 mg of 17-hydroxyprogesterone during the luteal phase in 5 women with short luteal phase induced significant elevations of plasma levels of estradiol and progesterone, as well as prolongation of the luteal phase. However, the same treatment was ineffective in the women with normal luteal phase. These data suggest that daily supplemental administration of 17-hydroxyprogesterone in the luteal phase is capable of stimulating the luteal function in the women having short luteal phase. This administration method might be a new therapy for the short luteal phase. The site of action of this therapy might lie in the ovarian level, because no significant change in FSH and LH secretion were demonstrated.
社団法人日本産科婦人科学会の論文
1977-12-01

EFFECT OF 17-HYDROXYPROGESTERONE UPON HUMAN OVARIAN FUNCTION AND ITS APPLICATION ON THE TREATMENT OF THE SHORT LUTEAL PHASE

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