特別掲載エチニールエストラヂオールの臨床的價値に就て

概要

論文の詳細を見る
Many estrogenic substances diminish in their activity when administered perorally, as they are destroyed in liver and gastrointestinal tract. Ethinyl-estradiol derived from estradiol, however, can be used perorally without losing its estrogenic activity. It was found first by Imhoffen a. Hohlweg, and Claubelg a. Ustum acknowledged its clinical effects. Many articles concerning this hormonal preparation have been published. In the present clinical experiment it was used for patients with the following disturbances in daily doses of 0.05 mg. The results are as follows: 1) Amenorrhea (6 cases): Effective in 5 cases. 2) Climacteric (8 cases): 4 completely, 3 slightly cured respectively, while ineffective in one case. 3) Dysmenorrhea (4 cases): Complete effect in 2 cases. 4) Menorrhagia (5 cases) and atypical bliding (6 cases): Effective in all cases. 5) I11 reactions (slight nausea, anorexia, headache, etc): Experienced only in 5 cases of 29. 6) The effects were also noted in 22 cases of 29 as revealed in the vaginal smears.
社団法人日本産科婦人科学会の論文
1951-07-01