産婦人科領域における肝臓機能檢査に就いて : 第1報驅梅療法特に短間隔大量注射療法の際における肝臓機能檢査

概要

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In the antisyphilitic therapy by means of arsenic compounds liver function test is necessary because of the possible ill effects of arsenic in large doses on organism which will be revealed to some extent in the decrease of the liver function. In the present experiment liver function was examined in syphilitic pregnant as well as non-pregnant women by means of Takada-Reaction, Brom-sulphalein-Test, Hypuricacid-Test and Urobilinogen-Test respectively, while carrying on infections of mapharsol in large doses (0.06 g daily from 10 to 110 days in succession) at short intervals. Results obtained are as follows: 1) No remarkable decrease of liver function, as revealed by the positive reaction of each test, was noted by any of those tests mentioned above. 2) In some cases positive reaction was observed indicating to some extent the decrease of liver function, but it is not necessarily to be interpreted as signifying the dangerous condition of the patient, because it was accompanied by disorders neither subjectively nor objectively. 3) Accordingly the administration of the arsenic compounds, for instance maphalsol, in large doses at short intervals is well applicable for clinical use as an antisyphilitic therapy.
社団法人日本産科婦人科学会の論文
1951-12-01