高頻度振動換気法の実験的研究 : 換気量,気道内圧,換気回数の呼吸循環機能に及ぼす影響

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Experimental studies of HFO were performed on rabbits to determine the proper setting of the MERA BMO Hummingbird 20N, which provided the best respiratory and circuratory support. After they had been anesthetized, animals were placed on the Hummingbird. PaO_2, PaCO_2, BP, CVP, HRand ITP were determined at different SV, MAP, and Fq. The following results were obtained ; 1. Best respiratory and circulatory data were obtained at 5ml/kg SV, 10cmH_2O MAP, and 15Hz Fq. HFO itself did not influence the mean blood pressure or the heart rate. 2. In an animal model of congenital diaphragmatic hernia produced by inflating a balloon in the thoracic cavity, HFO removed carbon dioxide more effectively than a conventional ventilator. 3. Since HFO did not ventilate the lung well through a narrow trachea less than 2.0mm I. D., an endotracheal tube used for HFO should be at least 3.0mm I. D.
1992-06-20