新生児胃破裂の発生機序に関する実験的研究

概要

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Taking note of the correlation between the onset and stresses including hypoxia, immaturity of gastric defense factors and environmental changes in the perinatal stage, we experimentally investigated rupture of the stomach. The results were as follows : 1) The body of the stomach tends to be affected by the stress of water immersion and by hypoxic conditions than does the antrum. 2) Acute gastric mucosal lesions were aggravated parti-cularly in the presence of hypofunction of the sympathe-tic nervous system under the stresses applied. 3) The rats under hypoxic conditions developed gastric mucosal lesions earlier than did those stresssed by water immersion, and the influence of hypoxic conditions was more than that of stress by water immersion. 4) These results suggest that a hypoxic condition may be one of the causes of neonatal gastric rupture, as well as perinatal stress and hypofunction of the sympathetic nervous system.
特定非営利活動法人日本小児外科学会の論文
1990-08-20