先天性胆道閉鎖症における肝および肝門部結合織塊の病理組織学的研究 : とくに肝内胆管と予後の関連について

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Histopathological studies of the liver and the bile duct remnants were carried out in 13 patients who had undergone hepatic portoenteroslomy for "non-correctable" type of biliary atresia. The patients were divided into two groups according to their postoperative course; Group A consisted of 10 patients who showed good excretion of bile and complete disappearance of jaundice postoperatively. Group B included 3 patients who showed good excretion of bile and complete disappearance of jaundice but prolonged liver dysfunction (n=2), or in whom jaundice persisted postoperatively (n=l). There was no remarkable difference of liver histology between these 2 groups, but de-generative changes of the bile duct epithelium in Group B. Histopathological examinations of the fibrous tissue transected at the porta hepatis disclosed that there were numerous minute bile ducts in all the specimens studied. Degenerative changes of the bile duct epithelium were, however, found in the specimens take from the patients who belonged to Group B. Three-dimensional reconstruction of the intraheptic bile ducts was carried out in 3 patients with biliary atresia; one belonged to Group A and other two patients belonging to Group B. Proliferation of intrahepatic bile ducts were noted but the main interlobular bile ducts and their branches were well preserved in the patient belonging to Group A, whereas there were obstruction and irregularity of the main interlobular bile ducts and their branches in the patients who belonged to Group B. The results of the present studies suggested that morphologic as well as functional changes of the inlrahepatic bile ducts are important to the prognosis of the patients with biliary atresia.
特定非営利活動法人日本小児外科学会の論文
1983-12-20

先天性胆道閉鎖症における肝および肝門部結合織塊の病理組織学的研究 : とくに肝内胆管と予後の関連について

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