合併奇形(特に十二指腸前門脈)を有する先天性胆道閉塞症の肝外胆管及び肝組織の形態学的検討

概要

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A morphological study of the remnant of extrahepalic bile duct and the wedge liver biopsies has been performed in 50 eases of uncorreciable biliary atresia with no associated anomalies and 14 combined by preduodenal porlal vein. There were 8 cases with rudiment1 or agenesis of the gallbladder, and 10 cases with agenesis of the common bile duct in the remnant of the extrahepatic bile duct combined by preduodenal portal vein. We classified these histologic specimens of the remnants into 3 types (Type I, ？ and ？), according to the findings of the ductal structure and the surrounding tissue. Almost all cases (96%) with no associated anomlies had the gallbadder of Type I (the internal diameter of the bile duct was more than 100 μ), but the gallbladders in two cases combined by preduodenal portal vein were replaced by the fibrous tissue as Type ？ (fibrosis without any duct or ductuli structure). Liver fibrosis in patients combined by preduodenal portal vein was more severe than those with no associated anomalies. We suppose that the difference of these morphological findings in the remnants and the liver biopsies may be the result of various developmental stages of the pathogenic process.
日本小児外科学会の論文
1982-08-20