Power Spectrum and Mutual Information Analyses of DNA Base (Nucleotide) Sequences

概要

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On the basis of the power spectrum analyses for the base (nucleotide) sequences of various genes, we have studied long-range correlations in total base sequences which are expressed as 1/ƒ^α, behaviour of the exponent a for the accumulated base sequences as well as periodicities at short range. In particular from the analysis of content rate distributions of α we have obtained the average value α^^- = 0.40 ± 0.01 and α^^- = 0.20 ± 0.01 for the human genes and S. cerevisiae genes, respectively. We have also performed the analyses using the mutual information function. We show that there exists a clear difference between the content rate distributions of correlation lengths for the sample human genes and the S. cerevisiae genes. We are led to a conjecture that the elongation of the correlation length in the base sequences of genes from the early eukaryote (S. cerevisiae) to the late eukaryote (human) should be the definite reflection of the evolutionary process.
社団法人日本物理学会の論文
2003-03-15