原著 Myotube-like structure in aged mouse

概要

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A small amount of the myotube-like structures (chained nuclei) are present in skeletal muscle independently of disease. These experiments show that the incidence of the myotube-like structure increases with the advance of age in mice. Moreover, it is shown that the DNA in the myotube-like structure is not fragmented. That is, the myotube-like structures were TUNEL (Terminal deoxynuc. leotidyl transferase (TdT) -mediated dUTP-biotin Nick-End labeling) negative. Moreover, we detected the polyadenylated mRNA around the myotube-like structure by using an in situ hybridization technique. This suggests that the myotube-like structure has transcription activity. This report indicates that the myotube-like structure is a useful indicator of aging in skeletal muscle.
日本体力医学会の論文
2002-08-01