ラット骨格筋々線維タイプ分化に及ぼす部分除神経の影響〔英文〕

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概要

• 論文の詳細を見る

• In this study, the rats were subjected to a partial denervation of the soleus muscle at the age of three weeks. After this, histochemical investigations were carried out to establish what kind of changes had occurred in the differentiation of the muscle fiber type as a result of this partial drop in muscle activity. The partial denervation was performed on the sinistral rat's soleus muscle, roughly 20% of the nerve bundles. After this the dextral soleus muscle was used as the contralateral control muscle and excised after two, four and eight weeks, respectively. Frozen sections of muscle were stained with HE and myosin ATPase. The cross sectioned specimen were used for determining the muscle fiber count and type II fiber count.. The results thus obtained show that, compared with the contralateral control muscle, the partially denervated muscle have an approximately 5% reduced muscle fiber count two and four weeks after the partial denervation, and the type II fiber count, too, decreased to approximately 2/3 and 1/5, respectively. However, at eight weeks post-operatively, the muscle fiber count for the partially denervated muscle become almost the same as that for the contralateral control muscle, while the type II fiber count has, at this stage, recovered to approximately half its contralateral control muscle. From these observations, it had been concluded that the reduction in muscle activity due to its partial denervation continues to act as a causal factor in the fiber type transformation until four weeks after the partial denervation. The muscles evaluated eight weeks post-operatively showed an increase in type II fiber over the count determined four weeks after the partial denervation, and the muscle fiber count l]ad also developed at eight weeks to value identical to that of the contralateral control muscles. Therefore, it has been concluded that the fiber type transformation in the muscle eight weeks after partial denervation is attributable to the reinnervation of the denervated muscle fibers due to the remaining intact motoneurons and to the resulting changes in motor unit size.

• 日本体力医学会の論文
• 1984-06-01

著者

• 成沢 三雄

  東海大学医学部

• NARUSAWA MITSUO

  東海大学医学部生理学教室

• Narusawa Mitsuo

  東海大学医学部生理

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