[SHORT REPORTS]Effects of Ryanodine on the Pacemaker Activity of Isolated Sinoatrial Node Cells of Rabbits

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概要

• 論文の詳細を見る

• The effects of ryanodine, a specific inhibitor of the sarcoplasmic reticulum (SR), on pacemaker activity were investigated in sinoatrial (SA) node cells isolated from rabbit hearts. An application of ryanodine (0.1 μM) resulted in slower and irregular spontaneous ecxitation of the SA node cells as well as shortening of the action potential duration, slowing of the diastolic depolarization rate, and miniature oscillation in the membrane potential during the diastole. In the presence of ryanodine ( 0.1 μM), hyperpolarization-induced oscillation of the membrane potensial was greatly enhanced. Ryanodine also triggered spontaneous excitation. In voltage-clamp experiments, ryanodine markedly enhanced oscillation of the membrane current traces. These findings suggest that the calcium handling by SR may play an important role in maintaining regular pacemaker activity in the SA node cells.

• 名古屋大学の論文

著者

• Watanabe E

  Department Of Cardiology Fujita Health University

関連論文

• Disorganization of Gap Junction Distribution in Dilated Atria of Patients With Chronic Atrial Fibrillation(CLINICAL INVESTIGATION)
• [SHORT REPORTS]Effects of Ryanodine on the Pacemaker Activity of Isolated Sinoatrial Node Cells of Rabbits

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