当帰芍薬散エキスとその血清の子宮筋収縮に対する作用

概要

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A study was performed to examine the effect of Toki-shakuyaku-san (TJ-23, TSS) on myometrial contraction of non-pregnant rats. TSS extract was applied to strips of dissected uterine muscle, and serum obtained from animals after oral administration of TSS (TSS serum) was applied to in situ and in vivo preparations. Prostaglandin F_<2α>(PGF_<2α>) and a high K^+ concentration (HK) were used for inducing muscle contraction. TSS extract and TSS serum reduced the strength of PGF_<2α>-induced contraction. The effect of TSS extract was dose-dependent, whereas that of TSS serum was dose-independent. HK-induced contraction was inhibited by TSS extract but facilitated by TSS serum. In vivo experiments to examine the effect of TSS serum on PGF_<2α>-induced uterine contractions demonstrated an inhibitory effect similar to that in in situ experiments. A method using serum obtained from animals orally administered Kampo medicine may be indispensable for examining the efficacy of such medicine when both in situ and in vivo experiments carried out by oral administration are difficult.
和漢医薬学会の論文
2000-08-10