EFFECTS OF DIPHENYL DIMETHYL DICARBOXYLATE ON ORAL TOLERANCE TO OVALBUMIN IN MICE

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概要

• 論文の詳細を見る

• The effects of diphenyl dimethyl dicarboxylate (PMC) on oral tolerance to ovalbumin (OVA) were investigated in C3H/HeN and BALB/c mice. Mice orally received 20 mg OVA or 2% starch solution were immunized 7 days later with an i.p. injection of 0.1 mg OVA in complete Freund's adjuvant (CFA). The effects of oral OVA and PMC on antibody production were assessed by ELISA of immunoglobulin (Ig) subclass level in serum collected 7 days after immunization. Oral tolerance was obtained enough on day 7 after immunization and was more effective in C3H strain than in BALB strain, associated mainly with decreases of anti-OVA IgG, IgG1, IgG2a and IgM levels. After oral OVA, oral administrations of PMC for 6 days significantly elevated anti-OVA IgG, IgG1, IgG2a and IgM levels in mice hyposensitized by the oral OVA. These findings indicate that PMC is an useful modulator of oral tolerance to OVA in these two strains.

• 日本トキシコロジー学会の論文
• 1995-09-25

著者

• Kim Joung

  Center For Food And Drug Safety Wonkwang University

• Kim Joung

  Center For Food And Drug Safety Won Kwang University

• AHN Young

  Center for Food and Drug Safety, Won Kwang University

• Ahn Young

  Center For Food And Drug Safety Wonkwang University

• Ahn Young

  Center For Food And Drug Safety Won Kwang University

関連論文

• PREVENTIVE EFFECTS OF DIPHENYL DIMETHYL DICARBOXYLATE ON THE IMMUNOTOXICITY OF CARBON TETRACHLORIDE IN ICR MICE
• THE EFFECTS OF ITRACONAZOLE ON THE IMMUNE RESPONSES IN ICR MICE
• EFFECTS OF DIPHENYL DIMETHYL DICARBOXYLATE ON ORAL TOLERANCE TO OVALBUMIN IN MICE

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