THE OPTIMUM pH OF SERUM ALKALINE PHOSPHATASE AFTER INDUCED CHOLESTASIS IN THE MALE RAT, MOUSE AND RABBIT

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概要

• 論文の詳細を見る

• The optimum pH of serum alkaline phosphatase (alk. P., EC 3.1.3.1) was investigated in adult male rats, mice and rabbits after fasting or after the induction of cholestasis by a single oral dose of 200 mg/kg alpha-naphthylisothiocyanate (ANIT). The nature of serum alk.P. was also studied with the inhibitory effects of three L-amino acids (L-phenylalanine, L-homoarginine and L-cystine) and by electrophoresis. In the rat, fasting as well as ANIT-treatment shifted the optimum pH of alk.P. from 9.4 to 10.0 due to a decrease in intestinal isoenzymes or due to newly appeared liver isoenzymes, while no shifting occurred in mouse and rabbit.

• 日本トキシコロジー学会の論文
• 1988-11-25

著者

• Kast A

  Nippon Boehringer Ingelheim Co. Ltd. Kawanishi Jpn

• Kast Alexander

  Department Of Experimental Pathology Nippon C.h. Boehringer Sohn Co. Ltd. Kawanishi Pharma Research

• YABE Tomokuni

  Department of Experimental Pathology, Nippon Boehringer Ingelheim Co., Ltd.

• Yabe Tomokuni

  Department Of Experimental Pathology Nippon Boehringer Ingelheim Co. Ltd.

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• ORAL ACUTE TOXICITY WITH STIMULANTS AND BLOCKERS OF BETA-ADRENOCEPTORS IN SINGLY-HOUSED OR AGGREGATED MICE
• THE OPTIMUM pH OF SERUM ALKALINE PHOSPHATASE AFTER INDUCED CHOLESTASIS IN THE MALE RAT, MOUSE AND RABBIT

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