PROTECTIVE EFFECT OF MALOTILATE (DIISOPROPYL 1,3-DITHIOL-2-YLIDENEMALONATE) ON CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN MICE AND RATS

概要

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The protective effect of malotilate was studied on the liver injury induced by carbon tetrachloride (CCl_4) in mice and rats. Plasma GOT and GPT activities were used as indices for the liver injury, and the liver was histopathologically examined. A remarkable suppressing effect on the liver injury was observed when malotilate was orally given 6 hr prior to oral administration of CCl_4 in mice and 3, 6 or 12 hr in rats. Malotilate was also effective in preventing the liver injury caused by intraperitoneal injection of CCl_4, indicating that the protective effect is not derived from the decreased CCl_4 absorption. The liver injury was suppressed even when malotilate was given 12 or 24 hr prior to oral administration of CCl_4 in mice and 24, 48 or 72 hr in rats. It may be the characteristic of malotilate that the protective effect lasts for a long period. It is supposed that the effect is due not only to the inhibition of the metabolic activation of CCl_4 but also the other action(s) of malotilate.
日本トキシコロジー学会の論文
1985-11-25