A PRELIMINARY STUDY ON LONG TERM TOXICITY TEST : Age-related alterations of bone marrow cellularity in Sprague-Dawley and Wistar rats

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概要

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• Age-related alterations in bone marrow cellularity were ex-amined on SD and Wistar SPF rats. Six rats / strain / sex were sacrificed at 58, 83, 109 and 123 or 135 weeks of age and quantitative assessment and categorization of the bone marrow cells were performed. One male and two female SD rats suffering from leukemia were excluded from statistics. Age-related increases of myeloblasts and plasma cells were observed in rats of either strain and either sex. Age-related decreases in percentages of lymphocytes were noticed in SD, but not in Wistar rats. Age-related alterations in absolute numbers of marrow lymphocytes were equivocal in either strain.

• 1985-02-25

著者

• Udaka Keiji

  Department Of Toxicology And Pathology Nippon Roche Research Center

• KANAZU Atsuo

  College of Med. Tech. & Nurs., Univ. of Tsukuba

• Kanazu Atsuo

  College Of Medical Technology And Nursing The University Of Tsukuba

関連論文

• 218 NON-OSMOTIC HEMOLYSIS OF MURINE ERYTHROCYTES (Continued)
• A PRELIMINARY STUDY ON LONG TERM TOXICITY TEST : Age-related alterations of bone marrow cellularity in Sprague-Dawley and Wistar rats
• FRAGMENTATION AND NON-OSMOTIC HEMOLYSIS OF RODENT ERYTHROCYTES
• 209 NON-OSMOTIC in vitro HEMOLYSIS OF MURINE ERYTHROCYTES
• CHEMICALLY INDUCED FRAGMENTATION OF MURINE ERYTHROCYTES
• "P-37 Depletion and repletion of Ca^ induce RBC fragmentation.

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