MUTAGENICITY AND DOMINANT LETHAL TEST OF KOJIC ACID : Ames test, forward mutation test in cultured chinese hamster cells and dominant lethal test in mice

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概要

• 論文の詳細を見る

• The mutagenicity of kojic acid was studied by means of reversion mutation test in bacteria (Ames test), forward mutation test in cultured Chinese hamster cells and dominant lethal test in mice. A positive result was obtained only in Ames test (TA 98, 1535 and 100) which was not modified by the presence of S-9 fraction. Thus, it is concluded that although kojic acid is a weak mutagen in bacteria, it is nonmutagenic in eukaryotic systems either in vivo or in vitro.

• 日本トキシコロジー学会の論文
• 1982-11-25

著者

• 渋谷 徹

  食品薬品安全センター・奏野研究所遺伝学研究室

• Sakamoto Kyoko

  食品薬品安全センター・奏野研究所遺伝学研究室

• MUROTA Tetsuro

  食品薬品安全センター・奏野研究所遺伝学研究室

• IWAHARA Shigeo

  食品薬品安全センター・奏野研究所遺伝学研究室

• IKENO Migiwa

  Sansho Seiyaku Co., Ltd.

• Ikeno Migiwa

  Sansho Seiyaku Co. Ltd.

関連論文

• MUTAGENICITY AND DOMINANT LETHAL TEST OF KOJIC ACID : Ames test, forward mutation test in cultured chinese hamster cells and dominant lethal test in mice

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