EFFECTS OF HEAVY METAL IONS ON THE ELECTRICAL PROPERTIES OF MUCOUS EPITHELIAL CELLS IN THE NEWT STOMACH
スポンサーリンク
概要
- 論文の詳細を見る
Zinc ion, Cu^<2+> and Cd^<2+> at 10^<-4>M or lower concentrations caused a marked decrease in the membrane potential of mucous epithelial cells in the isolated newt stomach without appreciable change in the effective membrane resistance and electrical coupling ratio. Cysteine and acetylpenicillamine antagonized the action of these ions. These ions as well as ouabain blocked the hyperpolarization of membrane due to an increase in intracellular Na+^. The effect of the ions on the relationship between external K^+-concentration and membrane potential was similar to that of ouabain. Discussion is made on the possibility that the ions inhibit active ion transport by combining with a SH-group of the cell mem brane and, thus, bring about a decrease in membrane potential.
- 日本トキシコロジー学会の論文
- 1978-02-15
著者
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YAMAMI Toshiaki
Department of Crown & Bridge Prosthodontics, Hiroshima University, School of Dentistry
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SHIBA Yoshiki
Department of Physiology, Hiroshima University, School of Dentistry
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MUNEOKA Yojiro
Department of Physiology, Hiroshima University, School of Dentistry
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KANNO Yoshinobu
Department of Physiology, Hiroshima University, School of Dentistry
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Shiba Yoshiki
Department Of Oral Physiology Graduate School Of Biomedical Sciences Hiroshima University
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Yamami Toshiaki
Department Of Crown And Bridge Prosthodontics Hiroshima University School Of Dentistry
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Kanno Yoshinobu
Department Of Otolaryng. Niigata University School Of Medicine
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