EFFECT OF HYPERPROLACTINEMIA INDUCED BY NEUROLEPTIC AGENT, TIMIPERONE, ON PORPHYRIN CONTENT OF MOUSE HARDERIAN GLAND
スポンサーリンク
概要
- 論文の詳細を見る
The histology and porphyrin content of the Harderian gland and the serum prolactin levels were examined in male B6C3F1 mice treated with neuroleptic buty-rophenones (timiperone and haloperidol) and treated concurrently with timiperone and 2-bromo- α -ergocryptine (bromocriptine), a potent suppressor of prolactin. Light-microscopically, both timiperone and haloperidol increased the number of accretions of porphyrin pigment within the Harderian gland lumina. Timiperone treatment of mice increased both the porphyrin content of the Harderian gland and the serum prolactin levels. Administration of bromocriptine to timiperone-treated mice distinctly prevented the rise in both tissue porphyrin and serum prolactin levels. In intact mice, bromocriptine also exerted inhibitory effects on both the Harderian gland potphyrin content and the serum prolactin level. Electron microscopic investigation revealed that the cytoplasm of type A cells in the Harderian glands of mice treated with timiperone contained trilaminar profiles similar to those seen in the intraluminar pigment masses. These results indicate that timiperone accelerates porphyrin secretion from the type A cells of the mouse Harderian gland by increasing the serum prolactin levels.
- 日本トキシコロジー学会の論文
- 1997-08-10
著者
-
Nomura Mamoru
イナリサーチ
-
Nakamura Miho
Drug Safety Research Laoboratory Daiichi Pharmaceutical Co. Ltd.
-
Nomura Mamoru
Drug Safety Research Laboratory Daiichi Pharmaceutical Co. Ltd.
-
Nomura M
Clinical Pathology Working Group The Japan Pharmaceutical Manufacturers Association
-
Nomura Mamoru
Drug Safety Research Laboratory Dai-ichi Pharmaceutical Co.ltd.
-
Kajimura Tetsuyo
Drug safety research center, Developmental research laboratories, Daiichi Pharmaceutical co.LTD.
-
Nomura Mamoru
Drug Safety Research Center Daiichi Pharmaceutical Co. Ltd.
-
Kajimura Tetsuyo
Drug Safety Research Center Developmental Research Laboratories Daiichi Pharmaceutical Co.ltd.
-
SATOH Hiroshi
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd.
-
Kajimura T
Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn
-
Nakamura Miho
Drug Safety Research Center Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
-
Satoh H
Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn
-
Satoh Hiroshi
Drug Safety Research Laboratory Daiichi Pharmaceutical Co. Ltd.
-
Nomura Mamoru
Japan Pharmaceutical Manufactures Association (jpma):daiichi Pharmaceuticals Co.ltd
-
Nomura Mamoru
Drug Safety Research Cehter Developmental Research Lab. Daiichi Pharmaceutical Co. Ltd.
関連論文
- Rapid Induction of Tumors in the Harderian Gland of Mice Receiving Urethane after Initiation with N-ethyl-N-nitrosourea
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Relationship between the β_3-Adrenoceptor Gene Variant and Body Fat in Japanese Children
- MALE REPRODUCTIVE TOXICITY STUDY OF NEFIRACETAM IN RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- Serum and articular cartilage concentration of levofloxacin in the juvenile and adult rats after the oral administration
- Effects of sulfated polysaccharides on bone metabolism in rats.
- Usefulness of measurement of glycosylated hemoglobin in erythrocytes as a diagnostic index for anemia in toxicity studies
- NEUTRALIZATION TEST OF SULFATED POLYSACCHARIDE WITH PROTAMINE
- 317 A POSSIBLE MECHANISM OF INCREASED SERUM ALKALINE PHOSPHATASE ACTIVITY INDUCED BY ORAL CONTRACEPTIVE IN RATS
- 227 EFFECT OF DP-1904, A THROMBOXANE A_2 SYNTHETASE INHIBITOR, ON THEOPHYLLINE-INDUCED CONVULSION
- Sample surveillance for clinical pathology testing.
- "B-14 Effect of coadministration of CPT-11 with cisplatin into portal vein on serum hepatic and renal parameters in rats.
- "A-8 Effect of quinoione antibacterial agents on lipopoiysaccharide toxicity in rats.
- Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
- BLOOD OF RATS AND DOGS FOR USE AS SURVEILLANCE SAMPLES : INVESTIGATION OF STORAGE AND TRANSPORTATION CONDITIONS
- EFFECT OF HYPERPROLACTINEMIA INDUCED BY PITUITARY GRAFTS OR CASTRATION ON PORPHYRIN CONTENT OF THE MOUSE HARDERIAN GLAND
- "P-78 An Electroretinogram (ERG) c-wave Recording Procedure in Rats for Evaluation of Visual Toxicity.
- Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT-11), in Rats
- Difference in cardiovascular responses to drug between conscious and anesthetized animals.
- Maintenance and Accuracy Control of Various Instruments for Clinical Pathology Examination in the Toxicity Study
- TREE-TYPE ALGORITHM FOR STATISTICAL ANALYSIS IN CHRONIC TOXICITY STUDIES
- 3B-12 Tree type algorithm for statistical analysis of repeated toxicity studies.
- "C-8 Evaluation on the consistency between statistical analysis and toxicological judgment.
- Effect of DX-9065a, a new anticoagulant drug, on pancreas
- TESTICULAR TOXICITY OF NEFIRACETAM AND IT'S ENDOCRINOLOGICAL MECHANISM IN MALE RATS.
- EFFECTS OF FOOD RESTRICTION ON SPERMATOGENESIS IN RATS
- A07 EFFECTS OF SEVERAL VEHICLES ON VARIOUS RARAMETERS FOR TOXICITY STUDY IN RATS
- "A-10 Changes Induced by compounds depressing reticuioendothelial system function in rats
- Examination of the effect of coadministration of anticancer drugs on the mouse lung.
- EXAMINATION OF CRYSTAL DISCRIMINATION IN URINARY SEDIMENT
- Male Reproductive Toxicity Study of Nefiracetam in Rats.
- Examination of Decreased Neutrophil Count Induced by Quinolone Antibacterial Agent, Levofloxacin, in Rats.
- INFLUENCE OF REPEATED ADMINISTRATION OF DIBUTYRYL CYCLIC AMP (DBcAMP) ON THE RAT LIVER
- THYROID HYPERTROPHIC EFFECT OF SEMOTIADIL FUMARATE, A NEW CALCIUM ANTAGONIST, IN RATS
- 3B-05 Basis studies for evaluation of blood biochemistry tests from experimental animals by automatic analyzers.
- EFFECT OF HYPERPROLACTINEMIA INDUCED BY NEUROLEPTIC AGENT, TIMIPERONE, ON PORPHYRIN CONTENT OF MOUSE HARDERIAN GLAND
- "P-14 The Early Changes and Reversibility of Testicular Lesions Caused by Nefiracetam in Rats.
- "C-12 Identification of epithelial cells in rat urinary sediments by a modified TiO stain.
- 229 EDEMA INDUCTION BY ARGININE SOLUTION IN RATS
- B-28 ATTENUATION OF TOXICITY OF ADRIAMYCIN BY ENTRAPMEN IN LIPOSOME
- Spontaneous Ectopic Sebaceous Glands (Fordyce's Granules) in the Oral Mucosa of Sprague-Dawley Rats
- CAN RETICULOCYTE CLASSIFICATION BY RNA CONTENT BE USEFUL FOR INDICATING ERYTHROPOIETIC ACTIVITY IN TOXICITY STUDIES ?
- APPLICATION OF Plasmodium berghei CHALLENGE MODEL AS HOST RESISTANCE IN IMMUNOTOXICOLOGICAL ASSESSMENT
- ENUMERATION OF LYMPHOCYTE SUBPOPULATIONS IN CYNOMOLGUS MONKEY USING FLOW CYTOMETRY, ANAE STAINING, OR ABC STAINING MEYHODS
- Genetic analysis of mutant colonies in mouse lymphoma L5178Y cells induced by quinolone antibacterial agent, levofloxacin.
- Effect of Bile-Duct Ligation and Unilateral Nephrectomy on Convulsion Induced by Quinolone Antibacterial Agent, Levofloxacin, in Rats.
- CHLOROQUINE RETINOPATHY IN RATS AND MICE
- Effect of DX-9065a, a new anticoagulant drug, on the cecum in rats.
- 23S3A-01-3 Toxicological Evaluation in Pharmaceutical Drug Exploratory Research.
- A SIMPLE LUMBAR INTRATHECAL INJECTION TECHNIQUE OF RAT
- GENOTOXICITY STUDIES OF p-DIMETHYLAMINOAZOBENZENE (DAB)
- Lack of Carcinogenicity of Reserpine in Transgenic Mice Carrying a Human Prototype c-Ha-ras Gene (RasH2 Mice)
- THE APPLICATION OF ELECTROCARDIOGRAPHY (ECG) TO TOXICOLOGICAL STUDIES IN RATS. IV. ANALYSIS FOR ADRIAMYCIN- AND ISOPROTERENOL-INDUCED CARDIAC LESIONS
- Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
- Characteristics of Local Invasion of Spontaneous Pituitary Carcinoma in the F344 Rat.