ALTERED TISSUE CONCENTRATION OF MINERALS IN SPONTANEOUS DIABETIC RATS(Goto-Kakizaki rats)
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概要
- 論文の詳細を見る
A relationship has been reported between trace elements and diabetes mellitus. This study examined the concentration of several trace elements (Zn, Mg, Ca, Fe, Cu, Mn, P) in each organ from spontaneous type 2 diabetic model rat (GK rat) and compared with control. Results showed that diabetic rat excreted 1.25-, 1.5-fold more zinc and magnesium, respectively, than control in the urine. Contents of zinc and magnesium in kidney and testis and fatty tissue were lowered significantly in GK rat. Zinc in liver and magnesium in lung were also lowered. Concentrations of other trace elements also changed in some organs from GK rats compared with those from control. These results demonstrate that trace element imbalances come out significantly in mild diabetes and the need to instruct a nutritionally balanced diet that takes account of trace elements in diabetes from the early stage.
- 日本トキシコロジー学会の論文
- 2004-08-30
著者
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Okuda Masayuki
Department Of Environmental Medicine Graduate School Of Science And Engineering Yamaguchi University
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Okuda M
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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Kunitsugu Ichiro
Departments Of Public Health And Laboratory Medicine Graduate School Of Medicine Yamaguchi Universit
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Sugiyama Shinichi
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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Okuda Masayuki
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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TAKITA Satoru
Human Environment and Preventive Medicine, Yamaguchi University Undergraduate School of Medicine
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WAKAMOTO Yukari
Human Environment and Preventive Medicine, Yamaguchi University Undergraduate School of Medicine
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KUNITSUGU Ichirou
Human Environment and Preventive Medicine, Yamaguchi University Undergraduate School of Medicine
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HOUBARA Tatsuya
Human Environment and Preventive Medicine, Yamaguchi University Undergraduate School of Medicine
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Takita Satoru
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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Wakamoto Yukari
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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Houbara Tatsuya
Human Environment And Preventive Medicine Yamaguchi University Undergraduate School Of Medicine
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Kunitsugu I
Departments Of Public Health And Laboratory Medicine Graduate School Of Medicine Yamaguchi Universit
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