アミノ配糖体系抗生物質療法コンサルテーション支援プログラムの作成

概要

論文の詳細を見る
When administering aminoglycoside antibiotics (AMGs), it is widely known that an individualized dosage regimen based on both measured serum concentrations and patient-specific pharmacokinetic parameters is essential to achieve desirable serum concentrations. The dosage regimen with AMG based on clinical pharmacokinetics, however, required a number of steps which involve a complicated set of calculations. We thus developed an AMG consultation support program for the purpose of applying it to routine practices. This program can readily estimate that pharmacokinetic parameters of each patient and can predict the peak and trough concentrations at a steady state. The program comprises three separate methods: the Sawchuk-Zaske dosing method, modified Sawchuk-Zaske dosing method and Dettli method. This enables a user to select one of them according to the routine clinical situation at hand. We believe that the system offers substantial support for effective and safe treatment of AMGs.
日本医療薬学会の論文
1994-08-20